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. 2021 Mar 2;14:1605–1611. doi: 10.2147/OTT.S296031

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© 2021 Gao et al.

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Identification of REG4 as a highly susceptible gene in response to RCT treatment in CRC. Volcano plot (A) and the distribution (B) of DEGs in tissues collected from patients receiving RCT treatment based on GSE15781 dataset. Red dots, significantly upregulated DEGs; blue dots, significantly downregulated DEGs; gray dots, no significant difference. P < 0.05 and fold change > 2 were considered as significant. (C) Top 10 enriched GO terms of significantly downregulated DEGs are indicated. (D) Venn diagram showing the shared genes between 250 identified genes and significantly downregulated DEGs obtained from GSE15781 dataset. (E) Module#2 exported from PPI network generated based on the shared genes.