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. 2021 Mar 2;14:1605–1611. doi: 10.2147/OTT.S296031

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© 2021 Gao et al.

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Experimental validation of the expression of REG4 in CRC. (A) REG4 is significantly upregulated in CRC tissues compared with normal colorectal tissues based on GEPIA. *, significantly different from normal tissues (p < 0.05). (B) The protein expression of REG4 in normal and CRC tissues, respectively. Representative immunohistochemistry staining images are obtained from the Human Protein Atlas online database (magnification, x40). (C) Western blot analysis of REG4 in tumor (T) and non-tumor (N) tissues collected from CRC patients. (D) The relative expression of REG4 in serum exosomes downloaded from exoRBase. (E) ROC curve analysis of REG4 based on GSE15781 dataset.