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. 2021 Mar 2;14:1605–1611. doi: 10.2147/OTT.S296031

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© 2021 Gao et al.

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Immunohistochemistry-based validation of REG4 as a potential biomarker for RCT sensitivity in CRC. (A) Representative immunohistochemical images of REG4 in RCT-resistant and RCT-sensitive CRC tissues collected from the clinic. Scale bar, 200 μm. (B) Quantification of REG4. **, significantly different from RCT-resistant CRC samples (p < 0.01). (C) ROC curve analysis of REG4 based on the microarray.