Table 4.
Correlation of virus NS-1 and virus titer assay.
| Compound ID | NS-1 IC50 (µM) |
E-protein IC50 (µM) | Viral titer reduction IC50 (µM) |
Cell Viability-Nuclei Counta |
|---|---|---|---|---|
| 1 | 0.6 | 0.88 | 0.12 | 57% at 30 µM |
| 6 | 0.84 | 0.99 | 0.11 | 59% at 30 µM |
| 25 | 2.5 | 2.10 | 0.82 | 61% at 30 µM |
| 41 | 0.8 | 1.38 | 0.84 | 59% at 30 µM |
| 34 | 1.7 | 2.34 | 0.81 | 63% at 30 µM |
| 28 | 2.5 | 3.73 | 0.82 | 59% at 30 µM |
| 61 | 1.6 | 1.49 | 0.4 | 55% at 30 µM |
| 38 | 11.4 | 8.32 | 1.8 | 68% at 30 µM |
| 31 | 12.9 | 5.5 | 8.6 | 73% at 30 µM |
a
Cytotoxicity was performed in SNB-19 cells, activity is normalized to DMSO control.