Fig. 1.

Similarity of HR2 regions between different coronaviruses. a Image of Spike protein (S1) of SARS-CoV-2. b S1 upon host cell interaction: conformational changes in trimer are occurring, exposing previously hidden HR2 domain regions (Wrapp et al. 2020), c monomeric part of (b), exposing domain with structural similarity (yellow—identical, orange—similar amino acids) towards corresponding MERS peptide, depicted on (d) and pan. (f). Protein BLAST analysis of used MERS protein is showing similarity towards the sequence in the genome of SARS-CoV-19. Sequence ID: QKJ68605.1. Crystal structure of HR2 domain for SARS-CoV-2 is currently not available, thus it is represented as a rectangle in (a) based on the last connected coordinates available in 6VSB structure