Table 1.
The main clinical characteristics of the pregnant women with ICP and the healthy pregnant women.
| Variable | Screening samples | P value | Validation samples | P value | ||
|---|---|---|---|---|---|---|
| ICP (n = 4) | Control (n = 4) | ICP (n = 54) | Control (n = 54) | |||
| Maternal age (y) | 26.50 ± 3.87 | 27.2 ± 1.50 | 0.231 | 28.90 ± 6.32 | 26.1 ± 4.87 | 0.220 |
| Gestational weeks | 37.85 ± 0.77 | 38.72 ± 0.63 | 0.076 | 37.93 ± 0.93 | 38.92 ± 0.95 | 0.041 |
| TBA (μmol/L) | 58.33 ± 12.4∗ | 3.51 ± 1.72 | 0.003 | 68.93 ± 50.35∗ | 5.34 ± 3.17 | 0.019 |
| ALT (IU/L) | 68.25 ± 24.76∗ | 17.01 ± 8.37 | 0.016 | 108.65 ± 101.44∗ | 16.1 ± 7.68 | 0.018 |
| AST (IU/L) | 82.71 ± 29.53∗ | 19.36 ± 5.42 | 0.028 | 106.78 ± 96.11∗ | 16.92 ± 8.34 | 0.018 |
TBA: total bile acid; ALT: alanine transaminase; AST: aspartate transaminase; statistical analysis was performed using t-tests; ∗P < 0.05 was considered significant.