Table 2.
Key nodes of component-target network.
| Herb | Node | Degree | Betweenness centrality |
|---|---|---|---|
| MDP/SQ | Quercetin | 112 | 0.36958975 |
| SNJ | Alanine | 104 | 0.41797809 |
| MDP/SCP | Kaempferol | 39 | 0.06875802 |
| DaH | Emodin | 29 | 0.04544646 |
| DL/SNJ | Guanidine | 27 | 0.08907938 |
| DL | Xanthinin | 25 | 0.08396791 |
| DL | Xanthine | 24 | 0.08789741 |
| CS | Baicalein | 23 | 0.02318204 |
| CS/MDP | Paeonol | 20 | 0.02429964 |
| CS/DaH/SQ | Beta-sitosterol | 20 | 0.02791937 |
| DL | Guanosine | 19 | 0.06005265 |
| SCP | 8-Isopentenyl-kaempferol | 18 | 0.02608771 |
| DaH | Aloe-emodin | 18 | 0.01960079 |
| CS/DaH/SQ | Stigmasterol | 18 | 0.03894191 |
| DL/SNJ | Cholesterol | 16 | 0.05001097 |
| CS | Ellagicacid | 15 | 0.01790131 |
| SNJ | Aspartic acid | 13 | 0.03120851 |
| SCP | Marmesin | 13 | 0.0165369 |
| DL/SNJ | 4-Guanidino-1-butanol | 12 | 0.03705792 |
| DaH | EUPATIN | 12 | 0.01168363 |
| CS/MDP | Benzoylpaeoniflorin | 12 | 0.01694236 |
| CS | Albiflorin_qt | 12 | 0.0149345 |
| SQ | Ginsenoside rb1 | 11 | 0.01531869 |
| SQ | Ginsenoside rh2 | 10 | 0.01552107 |
| CS | 1-O-beta-d-glucopyranosyl-8-o-benzoylpaeonisuffrone_qt | 10 | 0.00756521 |
| CS | Evofolin B | 10 | 0.01443392 |
| SQ | Notoginsenoside r1 | 9 | 0.00950678 |
| SQ | Ginsenoside f2 | 9 | 0.0087669 |
| DaH | Mutatochrome | 9 | 0.0191967 |
| DaH | Procyanidin B-5,3′-O-gallate | 9 | 0.02300249 |
| CS | Albiflorin | 9 | 0.00983057 |
| DiH | Stachyose | 8 | 0.00668771 |
| DaH | Palmidin A | 6 | 0.010557 |
| CS | 8-Debenzoylpaeonidanin | 4 | 1.33E-02 |
| CS | Paeoniflorin | 4 | 0.00892285 |
| Target | PTGS2 | 24 | 0.03392333 |
| Target | PTGS1 | 21 | 0.0243207 |
| Target | ESR1 | 17 | 0.04743098 |
| Target | MAPT | 15 | 0.02405041 |
| Target | PRKACA | 15 | 0.0125587 |
| Target | AR | 14 | 0.0546651 |
| Target | PTAFR | 14 | 0.01000789 |
| Target | PGR | 13 | 0.04286906 |
| Target | SLC6A2 | 13 | 0.01380599 |
| Target | SLC6A3 | 12 | 0.00778408 |
| Target | ADRB2 | 9 | 0.06270829 |
| Target | BAX | 8 | 0.01594706 |
| Target | ESR2 | 8 | 0.01052083 |
| Target | F10 | 8 | 0.0115522 |
| Target | PRKCA | 8 | 0.07827366 |
| Target | RXRA | 8 | 0.01249876 |
| Target | TOP2A | 8 | 0.01135885 |
| Target | CDK2 | 7 | 0.00778363 |
| Target | F7 | 7 | 0.00821191 |
| Target | TNF | 7 | 0.01279629 |
| Target | F2 | 6 | 0.00701019 |
| Target | IL1B | 6 | 0.06205608 |
| Target | NOS2 | 6 | 0.01729864 |
| Target | PRKCD | 6 | 0.00681975 |
| Target | VEGFA | 6 | 0.01754771 |
| Target | AKR1B1 | 5 | 0.02396875 |
| Target | JUN | 5 | 0.02537208 |
| Target | MMP9 | 5 | 0.00770693 |
| Target | NOS3 | 5 | 0.02534139 |
| Target | NR3C2 | 5 | 0.0069026 |
| Target | STAT1 | 5 | 0.01728485 |
| Target | ADORA1 | 4 | 0.04165433 |
| Target | ADRA2A | 4 | 0.01897542 |
| Target | CYP1A1 | 4 | 0.01430838 |
| Target | GSTP1 | 4 | 0.02559893 |
| Target | HIF1A | 4 | 0.02506214 |
| Target | PPARD | 4 | 0.02353186 |
| Target | TGFB1 | 4 | 1.03E-02 |
| Target | VDR | 4 | 8.61E-03 |