Time	Event
Patient 1
Day 1	Started neoadjuvant chemotherapy with Capecitabine and Oxaliplatin (CAPOX).
Day 7	Presented to Urgent Care with nausea, vomiting, weakness, shortness of breath, and pleuritic chest discomfort. Transthoracic echocardiogram (TTE) demonstrated a reduced left ventricular ejection fraction (LVEF) of <20%.
Day 7–23	Admission to Acute Cardiac Care Unit for inotropic support with milrinone.
Day 21	Repeat TTE demonstrated complete resolution of cardiac function.
Day 29	Discharged from hospital.
Day 36	Started on Raltitrexed and Oxaliplatin for management of rectal cancer.
Two months later	Cardiac computed tomography demonstrated no evidence of obstructive coronary artery disease.
Patient 2
Day 1	Started adjuvant chemotherapy with CAPOX
Day 2	Patient experienced two episodes of central chest pain while at rest with associated diaphoresis.
Day 3	Presented to Emergency Department due to increased chest pain and profound fatigue. Patient was tachycardic and hypotensive, unresponsive to fluids. Patient was found to have grossly reduced LVEF on point of care ultrasound.
Day 3–6	Admitted to Acute Cardiac Care Unit with cardiogenic shock requiring vasopressor and inotropic support with norepinephrine and milrinone.
Day 4	TTE revealed LVEF <20% with severely depressed right ventricular systolic function.
Day 5	Coronary angiography revealed no obstructive coronary artery disease.
Day 6	Patient weaned off norepinephrine and milrinone, transferred to Cardiology Ward.
Day 8	Cardiac magnetic resonance imaging (MRI) demonstrated LVEF of 32% with a hypokinetic left ventricle, with no evidence of myocarditis, infarction, or an infiltrative process.
Day 9	Discharged from hospital.
Four months later	Repeat cardiac MRI showed significant improvement of LVEF to 59%.