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. 2020 Dec 18;39(2):305–326. doi: 10.1007/s12640-020-00297-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The time-course effect of 25B-NBOMe on extracellular levels of a dopamine (DA), b serotonin (5-HT), c glutamate (GLU), and d acetylcholine (ACh) in the rat frontal cortex. Values are the mean ± standard error of the mean (SEM), n = 6 per experimental group. For ACh measurements, two consecutive dialysate fractions were pooled. The time of drug injection is indicated by an arrow. The basal extracellular levels were as follows: for DA, 0.99 ± 0.06 nM, n = 30; for 5-HT, 0.19 ± 0.008 nM, n = 30; for ACh, 36.5 ± 3.93 nM, n = 30; for GLU, 1.76 ± 0.16 μM, n = 30; *p < 0.0002 vs. control group (repeated measures ANOVA and Tukey’s post hoc test)