Table 2.
Associations of mRNA expression level of DE cluster A and cluster B genes with OA phenotypes
| Gene | JSN scoreb |
OP scoreb |
||
|---|---|---|---|---|
| OR (95% CI) | P-valuea | OR (95% CI) | P-valuea | |
| NR2F2 | 1.48 (1.26, 1.75) | 0.000002 | 0.88 (0.81, 0.95) | 0.0011 |
| MAP4K4 | 1.37 (1.13, 1.65) | 0.0012 | 1.00 (0.91, 1.1) | 0.9919 |
| TPST2 | 1.30 (1.07, 1.57) | 0.0076 | 0.97 (0.89, 1.06) | 0.4699 |
| HCLS1 | 1.30 (1.05, 1.6) | 0.0155 | 0.92 (0.83, 1.01) | 0.0641 |
| FCER1G | 1.25 (1.03, 1.53) | 0.0276 | 0.91 (0.83, 1.01) | 0.0768 |
| STAB1 | 1.22 (1.01, 1.47) | 0.0350 | 0.92 (0.83, 1.02) | 0.1259 |
| FLRT2 | 1.20 (1.01, 1.43) | 0.0419 | 0.91 (0.83, 1) | 0.0577 |
| CD248 | 1.24 (1.01, 1.53) | 0.0446 | 0.93 (0.85, 1.02) | 0.1043 |
| FYN | 1.19 (0.98, 1.44) | 0.0722 | 0.95 (0.86, 1.05) | 0.3319 |
| TMEM51 | 1.22 (0.98, 1.52) | 0.0729 | 0.92 (0.83, 1.02) | 0.1133 |
| EXT1 | 1.21 (0.98, 1.5) | 0.0757 | 1.00 (0.90, 1.11) | 0.9798 |
| RALA | 1.20 (0.98, 1.47) | 0.0774 | 0.93 (0.85, 1.01) | 0.0675 |
| VWF | 1.22 (0.97, 1.54) | 0.0934 | 0.94 (0.86, 1.03) | 0.1949 |
| CXCL12 | 1.18 (0.97, 1.44) | 0.1059 | 0.94 (0.85, 1.05) | 0.2683 |
| CTSH | 1.15 (0.94, 1.41) | 0.1625 | 0.91 (0.82, 1.00) | 0.0511 |
| SAMHD1 | 1.14 (0.94, 1.38) | 0.1888 | 1.03 (0.92, 1.16) | 0.5804 |
| MMP9 | 1.15 (0.92, 1.43) | 0.2149 | 0.94 (0.85, 1.03) | 0.1728 |
| MMP19 | 1.07 (0.88, 1.3) | 0.4725 | 1.02 (0.92, 1.14) | 0.6726 |
| EMILIN2 | 1.08 (0.86, 1.36) | 0.5190 | 0.94 (0.85, 1.04) | 0.2244 |
| LGALS3BP | 1.05 (0.86, 1.28) | 0.6448 | 1.02 (0.92, 1.13) | 0.7416 |
| PTPN6 | 0.96 (0.78, 1.18) | 0.6890 | 1.00 (0.90, 1.12) | 0.9332 |
| PECAM1 | 1.03 (0.85, 1.26) | 0.7499 | 1.00 (0.91, 1.11) | 0.9475 |
| GIMAP7 | 1.03 (0.84, 1.26) | 0.7564 | 1.02 (0.93, 1.13) | 0.6765 |
| STK17B | 1.03 (0.84, 1.25) | 0.7901 | 1.01 (0.91, 1.12) | 0.8208 |
| FLT4 | 1.03 (0.84, 1.26) | 0.8112 | 1.02 (0.93, 1.13) | 0.6464 |
a
P-value by generalized estimation equation (GEE) with mRNA expression level in preserved cartilage as dependent variable and age, sex, KL score and joint type as covariates.
b
The OP score or JSN score is defined as the sum of osteophyte grades (0–3) or JSN grades (0–3), respectively determined at the lateral and medial compartments of the tibio-femoral knee joint or at the inferior and superior compartments of the acetabular-femoral hip joint. JSN: joint space narrowing; OP: osteophyte.