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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Exp Neurol. 2020 Jun 5;331:113354. doi: 10.1016/j.expneurol.2020.113354

Figure 1. In Silico Motoneuron Model.

Figure 1.

(A) Shows the ten-state model Na channel model. The green vertical arrows represent transitions to fast-inactivated states, whereas the red horizontal arrows represent transitions to slow-inactivated states. IFT represents the total occupancy of all fast-inactivated states whereas IST represents that of the slow-inactivated states. Shows the steady-state occupancy of the open (B), fast-activated (C) and slow-inactivated states (D) as a function of membrane voltage. The black lines represent the features of the standard model, the blue and green lines represent changes in fast-inactivation process produced by hyperpolarizing the fast-inactivation voltage-dependence by either 5 (blue) or 10 mV (green). The red lines represent changes in state occupancy produced by doubling the rate at which slow-inactivated states are entered. Note that the steady-state persistent Na current (open state occupancy) is nearly identical for the 10mV shift in fast-inactivation and for the faster entry into the slow-inactivated states. However, this state-state is reached at different rates in the two cases.