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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Exp Neurol. 2020 Jun 5;331:113354. doi: 10.1016/j.expneurol.2020.113354

Figure 4. Firing Rate Modulation Nearly Eliminated.

Figure 4.

(A and C) Two-dimensional plots (left) shows the population of control (A, n = 6) and chemotherapy (C, n = 8) motoneuron’s capacity to modulate firing rate (frequency-current relationship: F-I) in response to varying levels of depolarizing current above rheobase (current-rheobase). Three-dimensional plot (right) highlights the density distribution of raw data across all injected currents levels. Narrowing topographical lines in B and D and hotter colors in A and C indicate higher density and correspond to higher peak values in plot to right. B and D show F-I plots from individual motoneurons comprising control and chemotherapy plots in A and C respectively.