Fig. 4.

The ceRNA network and its enrichment analysis by GO annotation and pathways identified by KEGG for Differentially expressed genes. The ceRNA network created by Cytoscape 3.8.3 (a). The connections DElncRNA (purple rectangle), DEmicroRNA (blue), and target genes (purple pink rhombus) were represented as nodes, and their interactions were denoted by lines. The top terms of enriched GO analysis (b). The top terms of enriched KEGG pathway [28–30] (c). Abbreviation: GO, the gene ontology; KEGG, the Kyoto encyclopedia of genes and genomes; BP, the biological process; CC, the cellular component. The details for actual gene IDs and GO descriptions were shown in Supplementary Table 5. The details for actual gene IDs per KEGG pathway were shown in Supplementary Table 6. We are grateful to Kanehisa Laboratories