Table 3.

Multivariate Logistic Regression for the risk factors of liver metastases at initial diagnosis of breast Cancer in the SEER database

Variable	Among Entire Cohort
	Multivariate
	OR (95% CI)	P Value
Age at diagnosis, y
18–40	1[Reference]
41–60	0.59 (0.54–0.66)	< 0.001*
61–80	0.46 (0.41–0.51)	< 0.001*
> 80	0.46 (0.40–0.54)	< 0.001*
Race
White	1[Reference]
Black	1.54 (1.41–1.67)	< 0.001*
Hispanic	0.82 (0.74–0.91)	< 0.001*
Asian or Pacific Islander	0.81 (0.72–0.92)	0.001*
American Indian/Alaska Native	0.93 (0.59–1.38)	0.725
Unknown	0.38 (0.19–0.68)	< 0.001*
Marital status
Unmarried a	1[Reference]
Married	0.64 (0.60–0.68)	< 0.001*
Unknown	0.83 (0.72–0.96)	0.013*
Insurance status
Uninsured b	1[Reference]
Insured	0.53 (0.45–0.63)	< 0.001*
Unknown	0.48 (0.35–0.67)	< 0.001*
Histology
Infiltrating duct carcinoma	1[Reference]
Lobular carcinoma	0.68 (0.59–0.77)	< 0.001*
Infiltrating duct and lobular carcinoma	0.66 (0.55–0.79)	< 0.001*
Other types c	1.25 (1.14–1.37)	< 0.001*
Pathological Grade
I	1[Reference]
II	3.89 (3.28–4.65)	< 0.001*
III/IV	8.59 (7.26–10.23)	< 0.001*
Unknown	20.75 (17.32–25.02)	< 0.001*
Extrahepatic metastatic sites to lung, brain and bone, No
0	1[Reference]
1	58.49 (53.84–63.57)	< 0.001*
2	123.15 (110.89–136.76)	< 0.001*
All 3	246.17 (195.34–310.33)	< 0.001*
Unknown	299.10 (240.01–372.94)	< 0.001*
Subtype
HR+/HER2−	1[Reference]
HR+/HER2+	3.13 (2.87–3.41)	< 0.001*
HR−/HER2+	4.75 (4.30–5.25)	< 0.001*
Triple-negative	1.92 (1.73–2.12)	< 0.001*
Unknown	1.48 (1.31–1.68)	< 0.001*

Notes: ^a including divorced, separated, single (never married), and widowed; ^b including insured, Insured/No specifics Any Medicaid; ^c including other histology of invasive breast cancer except Infiltrating duct carcinoma, Lobular carcinoma and Infiltrating duct and lobular carcinoma; + denotes positive; − denotes negative; * denotes a statistically significant P-value; HER2 Human epidermal growth factor receptor 2, HR Hormone receptor, OR Odds ratio, CI Confidence interval