Table 4.
Summary of significant associations of circRNAs with TNBC survival
| CircRNAs | Roles | TNBC Patients | Expression | Method | Sample type | Cut off | Univariate versus multivariate | Survival | HR (95%CI) | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| circSEPT9 | Oncogenic | 80 | Up | ISH | Tissue | 6 | Multivariate | OS | 3.042 (1.278–7.240), P = 0.012 | [49] |
| circUSP42 | Antitumor | 30 | Down | RT-qPCR | Tissue | Median | Univariate | OS,DFS | KM | [98] |
| circGNB1 | Oncogenic | 222 | Up | RT-qPCR | Tissue | NR | Multivariate | OS, DFS | OS, 2.148 (1.070–4.310), P = 0.031 | [59] |
| hsa_circ_0131242 | Oncogenic | 120 | Up | RT-qPCR | Tissue | NR | Univariate | OS | KM | [79] |
| circ-HER2 | Oncogenic | 59 | Up | RT-qPCR | Tissue | > Adjacent | Univariate | OS | KM | [75] |
| circPGAP3 | Oncogenic | 86 | Up | RT-qPCR | Tissue | Median | Univariate | OS,DFS | KM | [64] |
| circUBE2D2 | Oncogenic | 66 | Up | RT-qPCR | Tissue | Median | Univariate | OS | KM | [63] |
| circRAD18 | Oncogenic | 126 | Up | RT-qPCR | Tissue | Median | Multivariate | OS | 2.045 (1.010–4.143), P = 0.041 | [78] |
| circAGFG1 | Oncogenic | 80 | Up | ISH | Tissue | Median | Multivariate | OS | 6.072 (2.614–14.105), P < 0.001 | [57] |
| circFBXW7 | Antitumor | 473 | Down | RT-qPCR | Tissue | Mean | Multivariate | OS,DFS | OS, 0.215 (0.119–0.387), P = 0.001 | [74] |
| circTADA2A-E6 | Antitumor | 115 | Down | RT-qPCR | Tissue | NR | Univariate | OS,DFS | OS, 0.088 (0.011–0.714), P = 0.023; DFS, 0.094 (0.012–0.770), P = 0.028 | [48] |
| has_circ_069718 | Oncogenic | 35 | Up | RT-qPCR | Tissue | NR | Univariate | OS | KM | [81] |
| circAHNAK1 | Antitumor | 136 | Down | RT-qPCR | Tissue | Median | Univariate | OS, DFS | KM | [56] |
| circITCH | Antitumor | 91 | Down | RT-qPCR | Tissue | Median | Univariate | OS | KM | [52] |
| circTFCP2L1 | Oncogenic | 32 | Up | RT-qPCR | Tissue | − 6.58 | Univariate | DFS | KM | [55] |
| circKIF4A | Oncogenic | 240 | Up | RT-qPCR | Tissue | Mean | Univariate | OS, DFS | KM | [51] |
| circPLK1 | Oncogenic | 240 | Up | RT-qPCR | Tissue | Mean | Univariate | OS, DFS | KM | [54] |
| circANKS1B | Oncogenic | 165 | Up | RT-qPCR | Tissue | Median | Multivariate | OS | 3.29 (1.75–8.23), P = 0.008 | [47] |
| circUBAP2 | Oncogenic | 78 | Up | RT-qPCR | Tissue | Median | univariate | OS | KM | [53] |
| circEPSTI1 | Oncogenic | 240 | Up | ISH | Tissue | NR | univariate | OS, DFS | KM | [46] |
| circGFRA1 | Oncogenic | 222 | Up | RT-qPCR | Tissue | Mean | univariate | OS, DFS | KM | [29] |
NBC triple-negative breast cancer, OS overall survival, DFS disease-free survival, NR not report, qRT-PCR quantitative real-time PCR, ISH in situ hybridization, HR hazard ratio, CI confidence interval