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. 2021 Mar 6;22:160. doi: 10.1186/s12864-021-07480-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Comparative proteomics analysis of H. erinaceus. a Protein concentration determination using the BCA method. b Volcano plot analysis of DEPs of HEB_vs_HEA. c Volcano plot analysis of DEPs in HEC_vs_HEA. d The co-enriched KEGG pathways in HEB_vs_HEA and HEC_vs_HEA. The co-enriched KEGG pathways were obtained from the Venn analysis of enriched KEGG pathways in HEB_vs_HEA and HEC_vs_HEA in Additional files 10, 11, 12 and 13. The DEPs were used for KEGG pathway enrichment. Yellow indicates strong enrichment, and blue indicates weak enrichment. e STRING network analysis of enriched and differentially co-expressed proteins. These proteins were obtained from the Venn analysis of the DEPs in the enriched pathways in HEB_vs_HEA and HEC_vs_HEA. These circles represent the enrichment results using the co-upregulated proteins, and * represents the enrichment results using the co-downregulated proteins. f The pathway modules of carbohydrate metabolism leading to the production of glucose-6P. Red represents the apparent upregulation of MAE1(A6232), MLS1(A4695), PCK1(A5260) in the glyoxylate cycle modules (M00012), and PGK1 (A8906) in the glycolysis module (M00001)