Fig. 2.

Interferon response and TNFA signaling were upregulated during the pathogenesis of sepsis secondary to bacterial pneumonia.

Pathway enrichment analysis of significant hallmark gene sets comparing PBMCs from A. acute stage, B. stable stage and C. recovery stage with those from healthy controls (HCs). NES, normalized enrichment score. D. Dot plots showed the scaled expression level and percentage of key genes involved in interferon gamma response and TNFA signaling via NFκB and of PBMCs in HCs versus disease courses. The colour key from gray to purple indicated low to high expression levels. The dot size indicated the percentage of cells that expressed genes. E. GSEA enrichment plot of interferon gamma response of T/NK cells in disease courses versus HCs. F. GSEA enrichment plot of TNFA signaling via NFκB of myeloid cells in disease courses versus HCs. G. Genes were clustered according to their expression patterns during disease progression. Enriched GO terms for each cell type (biological processes) were showed at the right. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)