Fig. 5.

Expansion of plasma cells in the process of sepsis secondary to pneumonia.

A. Sub-clustering of B cells in healthy controls (HCs) and sepsis patients. B. Violin plots showed the scaled expression levels of canonically cell marker genes used for annotating each cell types. C. Heatmap of enriched GO terms for each cell type (biological processes). D. Histogram showed the proportion of each B cell type in HCs groups and different courses of disease. E. Violin plots showed the log₂(TPM/10 + 1) expression levels of HLA-DRA in disease stages versus HCs. F. Network of the potential signaling paths between the ligand IFNG and its predicted target gene, and the signaling/transcriptional regulators in these paths were visualized (blue: ligand; red: target genes; yellow: signaling/transcriptional regulators). The thickness of edge lines represented the weight of the interactions in the weighted integrated networks. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)