Fig. 7. Different immunological response presented between sepsis secondary to pneumonia induced by bacteria, influenza virus and SARS-COV-2. A. Violin plots showed the log₂(TPM/10 + 1) expression of genes enriched in interferon gamma response of sepsis secondary to pneumonia induced by bacteria, influenza virus and SARS-COV-2 for each patient. B. Pie plots showed the ratio of major cell type composition in sepsis secondary to pneumonia induced by bacteria, SARS-COV-2 and influenza virus. C. Histogram showed the proportion of each cell type in sepsis secondary to pneumonia induced by bacteria, SARS-COV-2 and influenza virus. D. GSEA enrichment plot of interferon gamma response of CD14⁺ Mono1 cells, NK1 cells, CD4⁺ Tpm cells, CD8⁺ Tem cells, CD8⁺ Te cells, Bm cells and Bn cells in sepsis secondary to pneumonia induced by bacteria versus SARS-COV-2. E. Dot plots showed the scaled expression level and percentage of exhaustion and apoptotic genes of T/NK cells in sepsis secondary to pneumonia induced by influenza virus, SARS-COV-2 and bacteria. The colour key from gray to blue indicated low to high expression levels. The dot size indicated the percentage of cells that expressed genes. Bac, bacteria; SARS, SARS-COV-2; Influ, influenza virus. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)