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. 2021 Mar 6;23:31. doi: 10.1186/s13058-021-01411-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — ctDNA ratios, treatment response, and impact on survival. ctDNA ratios for patients with non-progressive disease (green) vs progressive disease (red) after 15 days (a) or 30 days (b) of treatment. P values were calculated using Mann–Whitney tests. Median is highlighted by a solid black line. Patients highlighted with a star display increased ctDNA levels, which predict progression at 3 months. c–e Progression free survival of patients under palbociclib-fulvestrant therapy split by median ctDNA ratio at D15 (c, median D15 = 0.16), median ctDNA ratio at D30 (d, median D30 = 0.09), ctDNA ratio > 1 or ≤ 1 at D30 (e)