Table 2.
Comparison of MRI, PSMA-SPECT/CT and Clinical Parameters Between Good Responders and Poor Responders
| Parameters | Good Responders (N=21) | Poor Responders (N=5) | P value† | AUC |
|---|---|---|---|---|
| TBR | ||||
| Before CIRT | 16.277±15.746 | 10.591±8.874 | 0.200 | NA |
| After CIRT | 5.091±3.176 | 7.231±2.201 | 0.019 | NA |
| Δ TBR | −0.582±0.255 | −0.141±0.300 | 0.010 | 0.867 |
| ADCmean (× 10−3 mm2/s) | ||||
| Before CIRT | 0.741±0.199 | 0.892±0.201 | 0.138 | NA |
| After CIRT | 1.189±0.136 | 1.099±0.216 | 0.374 | NA |
| Δ ADCmean | 0.719±0.508 | 0.253±0.223 | 0.028 | 0.819 |
| Gleason Score (No. pts) | ||||
| 6–7 | 13 | 1 | 0.091 | NA |
| 8–9 | 8 | 4 | ||
| Risk Group (No. pts) | ||||
| Intermediate | 7 | 1 | 0.413 | NA |
| High | 8 | 1 | ||
| Very high | 6 | 3 | ||
Note: †Comparison between good responders and poor responders.
Abbreviations: MRI, magnetic resonance imaging; PSMA, prostate-specific membrane antigen; SPECT/CT, single photon emission computed tomography/computed tomography; TBR, tumor/background ratio; CIRT, Carbon ion radiotherapy; ADCmean, mean value of apparent diffusion coefficient; AUC, area under the curve; NA, not available.