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. 2021 Mar 3;14:859–867. doi: 10.2147/IDR.S292413

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© 2021 Liu et al.

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Maxing shigan decoction mitigated M. pneumoniae infection-induced pyroptosis in A549 cells by downregulating NLRP3. Cells overexpressing NLRP3 (oeNLRP3) or vector were treated with MXSG (0.2 mg/mL) for 24h. Bacteria-free broth and DMEM with 0.1% DMSO were used as controls. (A) Western blot analysis of NLRP3 expression; (B) Flow cytometry (PI staining); ELISA analysis of IL-18 (C), TNF-α (D), and IL-1β (E); (F) Western blot analysis of IL-1β, pro-IL-1β, caspase-1, pro-caspase 1 (F), and GSDMD-N (G). Data are expressed as mean ± SD (n = 3), **P < 0.01 vs Vehicle; ^#P < 0.05, ^##P < 0.01 vs MXSG + Vector.