Table II.

Effect of HA on pregnancy outcomes.^a

Outcome	Cohort	Number (%)	ORa (95% CI)	P a
LBEb	Low HA	224 (22.0%)	Reference
	Long HA exposure	341 (28.5%)	1.26 (1.02:1.55)	0.029
	Short HA exposure	391 (33.3%)	1.28 (0.97:1.67)	0.078
	HA pooled effect	732 (30.8%)	1.26 (1.03:1.54)	0.023
Multiple birthc	Low HA	43 (4.2%)	Reference
	Long HA exposure	66 (5.5%)	1.08 (0.71:1.64)	0.73
	Short HA exposure	80 (6.8%)	0.95 (0.56:1.60)	0.84
	HA pooled effect	146 (6.2%)	1.04 (0.69:1.57)	0.84
Biochemical pregnancyd	Low HA	337 (33.1%)	Reference
	Long HA exposure	447 (37.3%)	1.08 (0.90:1.31)	0.39
	Short HA exposure	519 (44.2%)	1.20 (0.94:1.54)	0.15
	HA pooled effect	966 (40.7%)	1.11 (0.93:1.33)	0.26
Clinical pregnancye	Low HA	252 (24.8%)	Reference
	Long HA exposure	368 (30.7%)	1.21 (0.99:1.48)	0.059
	Short HA exposure	434 (36.9%)	1.32 (1.02:1.72)	0.036
	HA pooled effect	802 (33.8%)	1.24 (1.02:1.50)	0.031
Early pregnancy lossf	Low HA	85 (8.3%)	Reference
	Long HA exposure	78 (6.5%)	0.76 (0.54:1.06)	0.11
	Short HA exposure	85 (7.2%)	0.84 (0.54:1.30)	0.42
	HA pooled effect	163 (6.9%)	0.78 (0.57:1.07)	0.12
Late miscarriageg	Low HA	28 (2.8%)	Reference
	Long HA exposure	28 (2.3%)	0.88 (0.51:1.53)	0.65
	Short HA exposure	40 (3.4%)	1.41 (0.72:2.77)	0.31
	HA pooled effect	68 (2.9%)	1.00 (0.60:1.67)	0.99

The data show clinical outcomes following ET procedures and the effects of long and short exposures to HA-rich culture medium (EmbryoGlue^®).

^a Adjusted LBE, multiple births, biochemical pregnancy, clinical pregnancy, early pregnancy loss and late miscarriage.

^b Deliveries that resulted in at least one baby.

^c Deliveries with more than one baby.

^d Positive βhCG test without a pregnancy on ultrasound scan, 3 weeks post-ET.

^e Pregnancies confirmed by ultrasound scan with the presence of a gestational sac and a foetal heartbeat at 12 6/7 weeks.

^f Losses occurring up to 13 weeks of gestation.

^g Losses between 14 and 24 weeks of gestation.

HA, hyaluronic acid; LBE, live birth event; OR, odds ratio.