Table III.
Singleton offspring sex, birthweight and gestational age.
| Outcome | Cohort | N (%) | ORa | P a | |
|---|---|---|---|---|---|
| * Sex ratio (male %) | Low HA | 86 (51.2%) | Reference | ||
| Long HA exposure | 150 (57.5%) | 1.39 (0.92:2.12) | 0.12 | ||
| Short HA exposure | 163 (53.4%) | 1.55 (0.91:2.64) | 0.11 | ||
| HA pooled effect | 313 (55.3%) | 1.43 (0.95:2.15) | 0.09 | ||
|
| |||||
| N | Mean (SD) | Differencea | P a | ||
|
| |||||
| Birthweight (g) | Low HA | 168 | 3265 (607) | Reference | |
| Long HA exposure | 261 | 3241 (586) | −8.2 (−127.1:110.7) | 0.89 | |
| Short HA exposure | 305 | 3280 (552) | 27.3 (−123.8:178.4) | 0.72 | |
| HA pooled effect | 566 | 3262 (568) | −0.9 (−117.1:115.3) | 0.99 | |
| Gestational age (weeks) | Low HA | 168 | 275 (16) | Reference | |
| Long HA exposure | 261 | 273 (18) | −0.9 (−4.1:2.4) | 0.60 | |
| Short HA exposure | 305 | 275 (13) | 2.1 (−2.0:6.3) | 0.31 | |
| HA pooled effect | 566 | 274 (16) | −0.3 (−3.4:2.9) | 0.88 | |
| GROW-adjusted birthweight (g) | Low HA | 168 | 3412 (520) | Reference | |
| Long HA exposure | 261 | 3406 (420) | −4.0 (−98.5:90.6) | 0.93 | |
| Short HA exposure | 305 | 3397 (454) | −51.5 (−171.6:68.6) | 0.40 | |
| HA pooled effect | 566 | 3401 (438) | −13.8 (−106.1:78.6) | 0.77 | |
| GROW birthweight centile | Low HA | 165 | 40 (30) | Reference | |
| Long HA exposure | 256 | 39 (28) | −1.1 (−7.1:4.9) | 0.71 | |
| Short HA exposure | 302 | 39 (28) | −4.6 (−12.1:3.0) | 0.24 | |
| HA pooled effect | 558 | 39 (28) | −1.8 (−7.7:4.0) | 0.54 | |
a
OR adjusted simultaneously for all the known potential confounders (patient age, previous attempts, ICSI, SET/DET, blastocyst transfer and crucially incubation system).
*
Reported for singleton births.
DET, double embryo transfer; HA, hyaluronic acid; OR, odds ratio; SET, single embryo transfer.