Figure 1.

Sevoflurane treatment induces the abnormality of mitochondrial pathway of apoptosis, mitochondrial dynamics, and mitophagy. Sevoflurane treatment could induce the reduction of MMP, the decrease of Bcl-2 expression, and the elevation of Bax expression, thereby initiating the mitochondrial pathway of apoptosis. Also, sevoflurane treatment could disturb mitochondrial dynamic by increasing Drp1 expression and reducing Mfn2. And the changes of LC3I/II ratio, p62, PINK1, Parkin, and Bnip3 expression induced by sevoflurane indicate that sevoflurane could disturb mitophagy.