Table 2.
Determined target information of BHD related to IS.
| UniProt ID | Protein name | Gene name |
|---|---|---|
| Q9UNQ0 | ABCG2 | ATP-binding cassette sub-family G member 2 |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor |
| P07550 | ADRB2 | Beta-2 adrenergic receptor |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase |
| P18054 | ALOX12 | Arachidonate 12-lipoxygenase, 12S-type |
| P09917 | ALOX5 | Arachidonate 5-lipoxygenase |
| P10275 | AR | Androgen receptor |
| O15392 | BIRC5 | Baculoviral IAP repeat-containing protein 5 |
| P42574 | CASP3 | Caspase-3 |
| P24385 | CCND1 | G1/S-specific cyclin-D1 |
| P29965 | CD40LG | CD40 ligand |
| P42771 | CDKN2A | Cyclin-dependent kinase inhibitor 2A |
| P02741 | CRP | C-reactive protein |
| P99999 | CYCS | Cytochrome c |
| Q9NRD8 | DUOX2 | Dual oxidase 2 |
| P03372 | ESR1 | Estrogen receptor 1 |
| Q92731 | ESR2 | Estrogen receptor 2 |
| P00742 | F10 | Coagulation factor Xa |
| P00734 | F2 | Thrombin |
| P13726 | F3 | Tissue factor |
| P08709 | F7 | Coagulation factor VII |
| P42262 | GRIA2 | Glutamate receptor 2 |
| P09601 | HMOX1 | Heme oxygenase 1 |
| P05362 | ICAM1 | Intercellular adhesion molecule 1 |
| O14920 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| P22301 | IL10 | Interleukin-10 |
| P01583 | IL1A | Interleukin-1A |
| P01584 | IL1B | Interleukin-1B |
| P05112 | IL4 | Interleukin-4 |
| P05231 | IL6 | Interleukin-6 |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 |
| P09960 | LTA4H | Leukotriene A-4 hydrolase |
| P11137 | MAP2 | Microtubule-associated protein 2 |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 |
| P03956 | MMP-1 | Matrix metalloproteinase-1 |
| P09238 | MMP-10 | Matrix metalloproteinase-10 |
| P08253 | MMP-2 | Matrix metalloproteinase-2 |
| P08254 | MMP-3 | Matrix metalloproteinase-3 |
| P14780 | MMP-9 | Matrix metalloproteinase-9 |
| P05164 | MPO | Myeloperoxidase |
| P01106 | MYC | Myc proto-oncogene protein |
| Q16236 | NFE2L2 | Nuclear factor erythroid 2-related factor 2 |
| P25963 | NFKBIA | NF-kappa-B inhibitor alpha |
| P29474 | NOS3 | Nitric oxide synthase, endothelial |
| P15559 | NQO1 | NAD(P)H dehydrogenase [quinone] 1 |
| P08235 | NR3C2 | Mineralocorticoid receptor |
| P78380 | OLR1 | Oxidized low-density lipoprotein receptor 1 |
| P12004 | PCNA | Proliferating cell nuclear antigen |
| P00750 | PLAT | Tissue-type plasminogen activator |
| P00749 | PLAU | Urokinase-type plasminogen activator |
| P27169 | PON1 | Serum paraoxonase/arylesterase 1 |
| P37231 | PPARG | Peroxisome proliferator activated receptor gamma |
| P23219 | PTGS1 | Prostaglandin G/H synthase 1 |
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 |
| P16581 | SELE | E-selectin |
| P05121 | SERPINE1 | Plasminogen activator inhibitor 1 |
| P10451 | SPP1 | Osteopontin |
| P01137 | TGFB1 | Transforming growth factor beta-1 |
| P07204 | THBD | Thrombomodulin |
| P01375 | TNF | Tumor necrosis factor |
| P19320 | VCAM1 | Vascular cell adhesion protein 1 |
| P15692 | VEGFA | Vascular endothelial growth factor A |