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. 2021 Feb 22;11:630139. doi: 10.3389/fimmu.2020.630139

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Copyright © 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adjacent sections through needle biopsies of non-tumoral liver and various intrahepatic cholangiocarcinomas and carcinomas of perihilar bile ducts immunostained with anti-tenascin-C (TNC) and anti-tenascin-W (TNW). (A) Non-tumoral liver (patient ID 5) is immunostained with TNC, but not TNW (200X). (B–D) Immunohistochemical examination of intrahepatic cholangiocarcinomas (ICC). Both TNC and TNW label the stroma of a moderately differentiated adenocarcinoma (B) strongly (patient ID 5; 200X). Antibodies to both tenascin-C and tenascin-W label the stroma of a well differentiated adenocarcinoma (Patient ID 1; C; 100X) and an adenosquamous carcinoma (Patient ID 8; D; 100X). (E, F) Immunolabeling of carcinomas of perihilar bile ducts (CPHBD) with TNC and TNW. The stroma of a moderately differentiated adenocarcinoma (Patient ID 11; E; 100X) and a well differentiated adenocarcinoma (Patient ID 13; F; 100X) show expression of both tenascin-C and tenascin-W. A third section in each series was stained with hematoxylin and eosin (H&E).