Figure 2.

Crosstalk between SIRT1-related signaling pathways. Relatively complex crosstalk exists between SIRT1-related signaling pathways. SIRT1 activates or inhibits its downstream targets, including PGC-1α, p53, Akt, FOXOs, TGF-β, NF-κB, AP-1, AMPK, and mTOR. Mutual activating or inhibiting effects exist among the downstream targets of SIRT1. In addition, some downstream targets of SIRT1 also feedback regulate SIRT1 activity. MicroRNAs are also involved in the regulation of SIRT1 and its downstream targets. ROS inhibit the activity of SIRT1, thereby altering the associated signaling pathways.