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Schematic image of the cascade of cytokines and transcription factors involved in the differentiation of Th1 and Th17 cells. IFN-γ, interferon-γ; IL, interleukin; RORγt, retinoid-related orphan receptor γt, STAT, signal transducer and activator of transcription; GATA, GATA transcription factor; TGF-β, transforming growth factor β, Th, T helper.
