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. 2021 Feb 22;12:598788. doi: 10.3389/fendo.2021.598788

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Copyright © 2021 Sun, Ma, Jin, Zheng, Wang and Ni

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavioral test in wild-type mice with HI injury treated with vehicle or melatonin as well as knockout mice with HI injury receiving vehicle and melatonin treatments as indicated. (A) TTC staining; (B) Negative geotaxis reflex test; (C) Cliff avoidance reflex test; (D) Open field test-center duration time; (E) Open field test-locomotor score; (F) Open field test-number of grooming; (G) Step through test-number of errors; (H) Step through test-latency avoidance period; (I) Cylinder test; (J) Foot fault test-forelimb foot fault test; (K) Foot fault test-hindlimb foot fault test; (L) Seizure threshold. [Two-way ANOVA, Bonferroni post hoc test (details are shown in text)].