Table 2.

Significant results for three-way analysis of variance.

	KO		WT
	Veh(Mean ± SD)	Mel (Mean ± SD)	Veh (Mean ± SD)	Mel (mean ± SD)
P10	5.342 ± 1.281	5.993 ± 0.628	5.476 ± 0.839	5.973 ± 0.691
P14	5.422 ± 1.362	6.145 ± 0.855	5.576 ± 0.792	6.223 ± 0.844
P18	6.378 ± 1.149	6.941 ± 1.206	6.608 ± 0.849	7.45 ± 0.894
P22	7.526 ± 1.370	7.668 ± 1.108	8.463 ± 0.849	9.289 ± 1.151
P26	9.438 ± 1.479	9.515 ± 1.108	10.436 ± 0.611	11.091 ± 1.222
P30	11.516 ± 1.769	11.605 ± 1.126	12.583 ± 0.595	13.414 ± 1.341
P34	13.334 ± 1.554	13.673 ± 1.092	14.48 ± 0.652	15.763 ± 1.012
P38	15.178 ± 1.375	16.504 ± 0.938	16.615 ± 0.593	18.069 ± 1.012
genotype	F = 7.709*		P = 0.018
treatment	F = 32.385**		P < 0.001
time	F = 1671.417**		P < 0.001
genotype × treatment	F = 0.610		P = 0.451
genotype × time	F=17.135**		P < 0.001
treatment × time	F=3.811*		P = 0.028
genotype × treatment × time	F=1.258		P = 0.305

Bonferroni’s method is used for multiple comparisons with all possible pairwise differences of means. WT, Wild-type mice with HI injury; KO, knockout mice with HI injury; Mel, melatonin; Veh, vehicle; ns, Not Significant ; *P < 0.05; **P < 0.001. [Three-way ANOVA, Bonferroni post hoc test (details are shown in text)].