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. 2021 Feb 22;9:618586. doi: 10.3389/fcell.2021.618586

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Copyright © 2021 Hou, Song, Gao, Zhang, Wang, Liu, Fu, Cao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulatory mechanism of CCCTC-binding factor (CTCF) on aging. CTCF binds to the DNA polymerase delta 1, catalytic subunit (POLD1) promoter, and stimulates POLD1 expression to inhibit the progression of aging. TSS, transcription start site.