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. 2021 Feb 22;12:605235. doi: 10.3389/fimmu.2021.605235

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Copyright © 2021 Santana, de Almeida, Lopes, Page, Oliveira, Souza, Ribeiro, Gutiérrez, Carvalho and Cardoso

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative plots of one experiment showing the frequency of CD4⁺TGF-β⁺ T lymphocytes in the different groups (A–C). Frequency of CD4 T lymphocytes expressing TGF-β after SEA stimulation from individuals without fibrosis and with different degrees of periportal fibrosis secondary to schistosomiasis (D). Correlations between this value and the portal branch wall thickness or the size of the liver left lobe of the patients that shows some level of fibrosis (E, F). Spearman’s rank correlation coefficient (r_s) and P value is shown. *p < 0.05 **p < 0.01.