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. 2021 Mar 8;6:109. doi: 10.1038/s41392-021-00499-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Cancer stem cells-derived EVs promote the formation of tumor immunosuppression microenvironment. EVs secreted by CSCs exhibited a tumor immunosuppression microenvironment through inhibiting the survival and proliferation of effector T cells and dendritic cells, as well as inducing the production of M2 macrophage, immunosuppressive monocytes, and neutrophils