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. 2020 Oct 20;28(3):1041–1061. doi: 10.1038/s41418-020-00636-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Schematic diagram demonstrating the study design of in vivo experiments on Pde6b^mut retinal degeneration. Representative hematoxylin and eosin (H&E) staining images of retinal tissues (B) and the corresponding quantitative analysis of ONL thickness (C). MSCT mesenchymal stem cell transplantation, EXOT exosomal transplantation, GCL ganglion cell layer, ONH optic nerve head. Scale bars = 50 μm. *P < 0.05 by the Kruskal–Wallis test for area under curve (AUC). N = 3 per group. Representative scotopic electroretinography (ERG) waveforms (D) and the corresponding quantitative analyses of amplitude changes of a-wave (E) and b-wave (F). *P < 0.05 by the Kruskal–Wallis tests. N = 3 per group. Representative photopic ERG waveforms (G) and the corresponding quantitative analysis of b-wave amplitude changes (H). *P < 0.05 by the Kruskal–Wallis tests. N = 3 per group. I Representative immunofluorescent (IF) staining images of retinal tissues showing cone photoreceptor bodies (white) counterstained by Hoechst 33342 (blue). Scale bars = 25 μm. Representative H&E staining images of retinal tissues (J) and the corresponding quantitative analysis of ONL thickness (K). Scale bars = 50 μm. *P < 0.05 by the Kruskal–Wallis test for AUC. N = 3 per group. Representative scotopic ERG waveforms (L) and the corresponding quantitative analyses of amplitude changes of a-wave (M) and b-wave (N). *P < 0.05 by the Kruskal–Wallis tests. N = 3 per group. Representative photopic ERG waveforms (O) and the corresponding quantitative analysis of b-wave amplitude changes (P). *P < 0.05 by the Kruskal–Wallis tests. N = 3 per group. Q Representative immunofluorescent (IF) staining images of retinal tissues showing cone photoreceptor bodies (white) counterstained by Hoechst 33342 (blue). Scale bars = 25 μm. R Representative terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL, green) staining images of retinal tissues counterstained by Hoechst 33342 (blue). Scale bars = 50 μm. Data represent median ± range for (C), (E), (F), (H), (K), (M), (N), and (P).