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. 2020 Oct 20;28(3):1026–1040. doi: 10.1038/s41418-020-00635-5

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Representative statistics analysis of CIB1 levels in two different data using the ONCOMINE database (www.oncomine.org). Data were filtered to display upregulation of CIB1 in LAC tissues compared to normal tissues (T: Tumor, N: normal tissues). a: Hou Lung Statistics; b: Landi Lung Statistics. B Representative immunohistochemically stained images of normal and LAC tissue using anti-CIB1 antibody: a, b: negative expression of CIB1 in normal lung tissue; c, d: negative expression of CIB1 in lung adenocarcinoma; e, f: weakly positive expression of CIB1 in lung adenocarcinoma; g, h: moderately positive expression of CIB1 in lung adenocarcinoma; i, j: Strong positive expression of CIB1 in lung adenocarcinoma;. C Relative mRNA expression level of CIB1 in LAC tumor tissue compare to normal tissues from 60 patients. D Quantitative RT-PCR results showed CIB1 expression levels in five LAC cell lines and normal bronchus cell lines. E Western blots results showed CIB1 expression levels in five LAC cell lines and normal bronchus cell lines. F, G Metastatic or advanced TNM stage LAC tumors had higher CIB1 expression levels compared with those of nonmetastatic or early TNM stage LAC tumors. H, I Kaplan–Meier analysis showed that the 5-year overall survival and disease-free survival for LAC patients with higher CIB1 expression levels were significantly shorter than those of patients with lower CIB1 expression level. *P < 0.05; **P < 0.01; ***P < 0.001; HR, hazard ratio.