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. 2021 Feb 22;13:630382. doi: 10.3389/fnagi.2021.630382

Figure 1.

Figure 1

Group-level differences in rCBF among all subjects and behavioral significance. (A) The result revealed altered rCBF regions among the groups including LPCUN and RMFG (GRF-corrected, cluster level p < 0.05, voxel-level p < 0.001). The color bar represents the z-scores. (B) Post hoc analysis of the altered rCBF in the LPCUN and RMFG regions in all the groups (Bonferroni correction, p < 0.05). Box plots show the 25 percentile, the median, and the 75 percentile, and whisker plots are in mean ± SD. *Represents statistical difference (p < 0.05). (C) Significant correlations between the altered rCBF and cognitive performance in the SCD, MCI, and AD groups after controlling the effects of age, gender, education, and GM volumes as covariates of no interest (p < 0.01). AD, Alzheimer's Disease; MCI, Mild Cognitive Impairment; SCD, Subjective Cognitive Decline; HC, Healthy Control; MMSE, Mini-Mental State Examination; rCBF, Regional Cerebral Blood Flow; LPCUN, Left Precuneus; RMFG, Right Middle Frontal Gyrus; GM, Gray Matter; GRF, Gaussian Random Field.