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. 2021 Feb 22;13:630382. doi: 10.3389/fnagi.2021.630382

Figure 2.

Figure 2

Group-level differences in ALFF among the subjects and behavioral significance. (A) The results showed the altered ALFF regions among the groups including LPCUN, LPCL, and LPCG (GRF-corrected, cluster level p < 0.05, voxel-level p < 0.001). Color bars represent the z-scores. (B) Post hoc analysis for the altered ALFF regions in all the groups (Bonferroni correction, p < 0.05). Box plots show the 25 percentile, the median, and the 75 percentile, and whisker plots are in mean ± SD. *Represents statistical difference (p < 0.05). (C) Significant correlations between the altered ALFF and neuropsychological tests in the SCD, MCI, and AD groups after controlling the effects of age, gender, education, and GM volumes as covariates of no interest (p < 0.01). AD, Alzheimer's Disease; MCI, Mild Cognitive Impairment; SCD, Subjective Cognitive Decline; HC, Healthy Control; MMSE, Mini-Mental State Examination; ALFF, Amplitude of Low-Frequency Fluctuation; LPCUN, Left Precuneus; LPCL, Left Paracentral Lobule; BPCG, Bilateral Posterior Cingulate Gyrus; GM, Gray Matter; GRF, Gaussian Random Field.