Table 4.

Significant differences pathways between the HFE and LFE groups.

Pathways ID	HFE1	LFE2	P-value	KEGG pathways annotation
Primary immune deficiency	0.000514	0.000457	0.004	Human Diseases; Immune System Diseases; Primary immunodeficiency
Glycan biosynthesis and metabolism	0.000197	0.000242	0.011	Unclassified; Metabolism; Glycan Biosynthesis and Metabolism
Dioxin degradation	0.000692	0.000642	0.015	Metabolism; Xenobiotics Biodegradation and Metabolism; Dioxin Degradation
D-Arginine and D-ornithine metabolism	2.3E-05	1.85E-05	0.023	Metabolism; Metabolism of Other Amino Acids; D-Arginine and D-Ornithine Metabolism
Chloroalkane and chloroalkene degradation	0.002457	0.002323	0.026	Metabolism; Xenobiotics Biodegradation and Metabolism; Chloroalkane and Chloroalkene Degradation
Xylene degradation	0.000684	0.000636	0.029	Metabolism; Xenobiotics Biodegradation and Metabolism; Xylene Degradation
Shigellosis	8.28E-09	6.9E-08	0.034	Human Diseases; Infectious Diseases; Shigellosis
Melanogenesis	0	4.08E-08	0.037	Organismal Systems; Endocrine System; Melanogenesis
C5-branched dibasic acid metabolism	0.003539	0.003523	0.039	Metabolism; Carbohydrate Metabolism; C5-Branched Dibasic Acid Metabolism
Nucleotide excision repair	0.004145	0.004006	0.044	Genetic Information Processing; Replication and Repair; Nucleotide Excision Repair
Carbohydrate metabolism	0.001776	0.001744	0.044	Unclassified; Metabolism; Carbohydrate Metabolism
Proteasome	0.000475	0.000463	0.046	Genetic Information Processing; Folding, Sorting and Degradation; Proteasome
Starch and sucrose metabolism	0.011162	0.011075	0.049	Metabolism; Carbohydrate Metabolism; Starch and Sucrose Metabolism
Phenylalanine, tyrosine, and tryptophan biosynthesis	0.008417	0.008315	0.049	Metabolism; Amino Acid Metabolism; Phenylalanine, Tyrosine, and Tryptophan Biosynthesis

The significance of the gene distribution between the groups was analyzed using nonparametric test with a P-value < 0.05.

Abbreviations: HFE, high feed efficiency; KEGG, Kyoto Encyclopedia of Genes and Genomes; LFE, low feed efficiency.

¹Relative abundance of functional prediction pathways in the HFE group.

²Relative abundance of functional prediction pathways in the LFE group.