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. 2021 Feb 22;11:609060. doi: 10.3389/fimmu.2020.609060

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Copyright © 2021 Shi, Su, Zhang, Shi, Zhou, Wang, Wang, Shi, Wei, Wang, Auwerx, Schoonjans, Yu, Pan, Zhou and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TGR5 deficiency in NASH mediates macrophages polarization in response to PA treatment. (A, B) Representative immunofluorescence images of liver samples were stained with iNOS and CD206 antibodies (scale bar, 50 μm). (C–H) The mRNA levels of M1 markers (CD68, CD86 and iNOS) and M2 markers (CD163, Arg-1 and CD206) were analyzed by real-time qPCR (n = 3/group). (I) CD206, iNOS, p-STAT1, STAT1, p-STAT6, STAT6 and GAPDH protein levels were detected by western blotting. (J) The relative quantities of CD206, iNOS protein to GAPDH, p-STAT1 protein to STAT1, p-STAT6 protein to STAT6. Data represent mean ± SD; *P < 0.05.