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. 2021 Feb 22;11:609060. doi: 10.3389/fimmu.2020.609060

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Copyright © 2021 Shi, Su, Zhang, Shi, Zhou, Wang, Wang, Shi, Wei, Wang, Auwerx, Schoonjans, Yu, Pan, Zhou and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of the NLRP3 inflammasome promotes macrophages polarization in TGR5^-/- mice with NASH. (A–F) mRNA levels of M1 markers (CD68, CD86 and iNOS) and M2 markers (CD163, Arg-1 and CD206) were analyzed by real-time qPCR (n = 3/group). (G) CD206, iNOS, p-STAT1, STAT1, p-STAT6, STAT6, and GAPDH protein levels were detected by western blotting. (H) The relative quantities of CD206, iNOS protein to GAPDH, p-STAT1 protein to STAT1, p-STAT6 protein to STAT6. Data represent mean ± SD; *P < 0.05.