Table 2.
Association between Glycolytic Enzyme Level and the BRAFV600E Mutation
| Variable | BRAF WT (n=12) | BRAFV600E (n=71) | P value |
|---|---|---|---|
| GLUT1 expression | 0.788 | ||
| Low | 1 (8.3) | 7 (9.9) | |
| Moderate | 10 (83.3) | 61 (85.9) | |
| High | 1 (8.3) | 3 (4.2) | |
|
| |||
| PKM2 expression | 0.145 | ||
| Low | 0 | 2 (2.8) | |
| Moderate | 6 (50.0) | 16 (22.5) | |
| High | 6 (50.0) | 53 (74.6) | |
|
| |||
| LDHA expression | 0.020 | ||
| Low | 3 (25.0) | 3 (4.2) | |
| Moderate | 4 (33.3) | 17 (23.9) | |
| High | 5 (41.7) | 51 (71.8) | |
Values are expressed as number (%).
WT, wild-type; GLUT1, glucose transporter 1; PKM2, pyruvate kinase isoform M2; LDHA, lactate dehydrogenase A.