Table 2.

Estimates of model terms of interest.

Cog Out	Term of interest	Std beta	Rob std beta	Chi2	p-value
ADAS-cog	T * SNE	–0.004	–0.009	0.044	0.83338
ADAS-cog	T * SNE * AV45	0.088	0.066	8.020	0.00463*
ADAS-cog	T * SNE * TAU	–0.074	–0.057	8.088	0.00446*
CDRSOB	T * SNE	0.098	0.090	4.284	0.03848*
CDRSOB	T * SNE * AV45	0.276	0.216	56.736	<0.00001*
CDRSOB	T * SNE * TAU	–0.069	–0.073	5.876	0.01535*
CDRSOB	T * SNE * WMHV	–0.058	–0.046	5.997	0.01433*
MMSE	T * SNE	0.074	0.085	6.405	0.01138*
MMSE	T * SNE * AV45	0.024	0.026	4.422	0.03549*
MMSE	T * SNE * TAU	–0.030	–0.026	9.914	0.00164*

Cog Out, Cognitive outcome; Std beta, standardized regression coefficient; Rob std beta, standardized regression coefficients of robust mixed-effects regression; ADAS-cog, Alzheimer’s disease assessment scale; CDRSOB, clinical dementia rating sum of boxes; MMSE, mini-mental state examination; SNE, global efficiency of structural networks of reconstructed white matter tracts connecting segmented gray matter regions. *Statistically significant.