Table 2.

Thromboinflammatory parameters in serum/plasma at admission to the ICU (n ≤ 65).

	n	Median		IQR	Reference range	p
General inflammation:
IL-6	37	103	⇡	46–167	<7.0 ng/L	****
CRP	63	169	⇡	118–235	<5 mg/L	****
Ferritin	52	1,074	⇡	515–2,477	25 - 310 µg/L	****
Procalcitonin	59	1.05	⇡	0.19–1.10	<0.05 µg/L	****
Neutrophil count	56	5.8	⇡	3.95–7.58	1.5–5.4 × 109/L	****
Platelet count	64	214	⇢	147–300	150–350 × 109/L	****
Complement system:
Classical pathway1	22	98	⇢	82–112	80%–120%	**
Alternative pathway 1	22	107	⇢	78–125	50%–150%	ns
C1q2	65	91	⇣	68 –111	70–300 mg/L	***
MBL2	65	625	⇡	303–1,112	288–611 kU/L	****
C42	22	0.23	⇢	0.19–0.39	0.13–0.32 g/L	**
C32	65	1.21	⇢	0.97–1.46	0.67–1.29 g/L	****
Factor B2	22	0.61	⇡	0.53–0.70	0.19–0.50 g/L	****
C4d3	55	1,966	⇡	551–3,815	<1,000 ng/ml	****
C3a3	65	253	⇡	164–390	<200 µg/L	****
C3d,g3	65	6.8	⇡	5.7–8.3	<5.3 mg/L	****
sC5b-93	65	142	⇡	103–213	<50 µg/L	****
Kallikrein/kinin system:
FXII2	62	21.9	⇣	19.4–27.9	14.9–44.9 mg/L	ns
Prekallikrein2	65	26.1	⇣	20.7–29.0	30.4–62.0 mg/L	****
HK2	62	30.6	⇣	26.0–36.9	27.8–102.6 mg/L	****
Coagulation system:
APTT1	16	38	⇢	33–40	30–42 s	ns
INR1	20	1.1	⇢	1.0–1.2	0.9–1.2 INR	ns
Fibrinogen2	11	6.5	⇡	5.1–7.6	2.0–4.2 g/L	****
TAT3	64	47	⇡	33–67	<10 µg/L	****
Fibrinolysis system:
D-dimer 3	61	1.40	⇡	0.88 – 2.65	<0.50 mg/L	****

¹Functional assays of the cascade systems in plasma.

²Plasma protein concentration.

³Activation product plasma concentration.

Fisher´s exact test was used. IQR, interquartile range; MBL, mannose binding lectin; HK, high molecular weight kininogen; APTT, activated partial thromboplastin time; INR, international normalized ratio; TAT, thrombin-antithrombin.

** <0.01, **** <0.0001.