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. 2021 Feb 22;11:623952. doi: 10.3389/fonc.2021.623952

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Copyright © 2021 Récher

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms underlying hyperferritinemia in acute myeloid leukemia (AML) and the role of ferritin in AML physiopathology. Elevated serum ferritin levels are due to a dysregulated inflammatory response, chemotherapy, disease burden, and the release by leukemic cells. This is further sustained by iron overload due to red blood cell transfusion during induction and consolidation treatment. Extracellular and intracellular activities of ferritin may induce resistance to chemotherapy, myelosuppression and disease progression resulting in a poor outcome.