Table 1.
Multiple functions exerted by YT521-B homology (YTH) family proteins in various tumor.
| Cancer type | YTH domain proteins | Related target | Role in cancer | References |
|---|---|---|---|---|
| Liver cancer | YTHDF1 | regulates the cell cycle and metabolism | (23) | |
| YTHDF2 | SOCS2 | promotes proliferation and migration | (24) | |
| YTHDF2 | EGFR | inhibits liver cancer cell growth and proliferation | (25) | |
| YTHDF2 | IL11 SERPINE2 | Inhibits tumor-associated inflammation and tumor angiogenesis | (26) | |
| Colorectal cancer | YTHDF1 | Wnt/β-catenin pathway | promotes the occurrence and development of colorectal cancer | (27) |
| YTHDF3 | Gas5 | promotes proliferation and metastasis | (28) | |
| YTHDC2 | HIF-1α | promotes metastasis | (29) | |
| Gastric cancer | YTHDF2 | promotes cell proliferation and inhibit apoptosis | (30) | |
| Esophageal cancer | YTHDC2 | p53、NF-kappa B and JAK-STAT pathway | inhibits esophageal cancer cell growth | (31) |
| Ovarian cancer | YTHDF1 | EIF3C | promotes tumorigenesis and metastasis | (32) |
| NSCLC | YTHDF1 | CDK2 CDK4 cyclinD1 | promotes NSCLC cell proliferation and xenograft tumor formation | (33) |
| YTHDF2 | 6-PGD | enhance tumor growth | (34) | |
| Pancreatic cancer | YTHDF2 | YAP | inhibits migration and invasion | (35) |
| YTHDF2 | Akt/GSK3b/CyclinD1 pathway | promotes proliferation | (35) | |
| Bladder cancer | YTHDF1 YTHDF3 | ITGA6 | promotes the growth and progression | (36) |
| YTHDF2 | SETD7 KLF4 | promotes migration | (37) | |
| AML | YTHDF2 | TNFRSF2 | promotes leukemic stem cells development and AML initiation | (38) |
| Breast cancer | YTHDF1 YTHDF3 | poor prognosis | (39) | |
| YTHDF3 | ST6GALNAC5、GJA1、EGFR VEGFA | Promotes brain metastasis | (40) | |
| Melanoma | YTHDF1 | HINT2 | promotes cell growth and inhibits apoptosis | (41) |
NSCLC, non-small cell lung cancer; AML, Acute Myeloid Leukemia.