Table 4. Publication bias on therapeutic efficacy and adverse events.

Publication Bias	Therapeutic efficacy			Adverse events
	ORR	DCR	QIR	Gastrointestinal adverse effects	Leukopenia	Thrombocytopenia	Hepatotoxicity
Begg	0.032	0.747	0.150	0.274	1.000	0.373	0.152
Egger	0.018	0.947	0.116	0.231	0.149	0.031	0.314
Trim and fill analysis
before	P<0.0001					P<0.0001
after	P<0.0001					P<0.0001

Notes: Parameters discussed in over 10 papers were conducted bias analyses.

Abbreviations: DCR, disease control rate; ORR, overall response rate; QIR, quality of life improved rate.