Table 1.

Top consistently chosen variables across folds.

Variable name	Normalized score (%)	Full gene name	Overlap with known gene sets	Adj p-value (from DEG analysis)	KS test
					Statistic	p-value
RETN	100	Resistin	PERSEVERE (14)	6.65 × 10−5	0.44	2.08 × 10−7
IL1R2	100	Interleukin 1 Receptor Type 2	Sweeney et al. (17)	1 × 10−4	0.34	1 × 10−4
PRISM Score**	100	Not applicable	Not applicable	Not applicable	0.46	3.08 × 10−8
SDC4*#	100	Syndecan-4	Nikaido et al. (48)	1.93 × 10−10	0.49	3.98 × 10−9
TGFBI	100	Transforming Growth Factor Beta Induced	PERSEVERE XP (15), Sweeney et al. (17)	1.36 × 10−5	0.41	1.15 × 10−6
CEACAM8	96	CEA Cell Adhesion Molecule 8	Sweeney et al. (17)	1 × 10−4	0.44	1.35 × 10−7
MMP8	92	Matrix metalloproteinase-8	PERSEVERE (14)	2 × 10−4	0.39	4.51 × 10−6
ELANE (ELA2)	92	Elastase, Neutrophil Expressed	PERSEVERE (14)	2 × 10−3	0.37	1.59 × 10−5
CLEC5A*	92	C-Type Lectin Domain Containing 5A		8.87 × 10−5	0.37	2.35 × 10−5
TCN1*	92	Transcobalamin 1		1 × 10−4	0.39	6.59 × 10−6
CEP55	92	Centrosomal Protein 55	PERSEVERE XP (15), Sweeney et al. (17)	3.78 × 10−6	0.40	2.20 × 10−6
MME	92	Membrane Metalloendopeptidase	PERSEVERE XP (15)	2 × 10−4	0.39	4 × 10−6
MS4A3*	92	Membrane Spanning 4-Domains A3		7 × 10−3	0.34	1 × 10−4
DEFA4	92	Defensin Alpha 4	Sweeney et al. (17)	5.8 × 10−2	0.30	1 × 10−3
HCAR3*	88	Hydroxycarboxylic Acid Receptor 3	Kangelaris et al. (49)	2 × 10−3	0.33	1 × 10−4
LCN2	88	Lipocalin-2	PERSEVERE (14)	9.6 × 10−5	0.39	3.8 × 10−6
OLAH*	84	Oleoyl-ACP Hydrolase Olfactomedin 4	Basu et al. (50)	1.1 × 10−2	0.31	6 × 10−4
OLFM4	68	Olfactomedin 4	Basu et al. (50)	1.8 × 10−3	0.33	1 × 10−4
LTF	68	Lactoferrin	PERSEVERE (14)	3.9 × 10−3	0.34	9.5 × 10−5
PLCB1*#	68	Phospholipase C Beta 1			0.3	1 × 10−4
NLRP1*#	68	NLR Family Pyrin Domain Containing 1		2.56 × 10−6	0.45	5.41 × 10−8

^*Novel genes.

^#Non-DEGs.

^**Clinical variable. Novel Biomarkers are indicated in bold.