Table 2.

Top genomic predictors obtained during external validation analysis.

Validation dataset identifier	Cohort type	Best AUROC	Gene names
GSE54514#	Adult	0.723	MMP8, CEACAM8, LCN2, RETN, CLEC5A, TGFBI, CEP55, MME, OLAH, SDC4
E-MEXP-3850*	Pediatric	0.956	MMP8, TCN1, OLAH, CEP55, PLCB1, OLFM4, HCAR3, TGFBI, MS4A3, CEACAM8, SDC4
E-MEXP-3567#	Pediatric	0.83	MMP8, CEACAM8, LCN2, RETN, CLEC5A, TGFBI, CEP55, MME, OLAH, SDC4
GSE40586#	MIxed	0.822	MMP8, OLFM4, CEACAM8, RETN, LTF, HCAR3, IL1R2, MS4A3, TGFBI, DEFA4, MME, OLAH, SDC4, PLCB1, NLRP1

^*Kolmogorov-Smirnov test was performed on the ranked list of genes obtained using the tree-based variable importance method. Only the significant (p < 0.1) results are included in this list.

^#List of genes selected using the LASSO-based variable selection technique.