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. 2021 Feb 22;11:554922. doi: 10.3389/fendo.2020.554922

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Copyright © 2021 Johansson, Søndergaard, Jorns, Kutter and Ellis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of FGF19 did not alter downregulation of CYP7A1 mRNA expression by chenodeoxycholic acid (CDCA). Primary human hepatocytes were treated with siRNA targeting FGF19 or non-targeting control. (A) FGF19 mRNA expression, (B) protein levels in medium in control cultures, after induction by 10 µM CDCA. (C) CYP7A1 mRNA expression, (D) cholic acid (CA) concentration in cell medium. Data is presented as median with interquartile range (IQR). Friedman test was used to assess differences between control and treatments and Dunn’s multiple comparison test was used post-hoc. Each colored dot represents one individual case (n = 3). *p < 0.05.